Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hand1  heart and neural crest derivatives expressed 1   (Synonyms: bHLHa27, eHAND, Ehand1, Hxt, Th1, Thing1)
Results	Reference
1*	J:119296 Arnold SJ, Maretto S, Islam A, Bikoff EK, Robertson EJ, Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. Dev Biol. 2006 Aug 1;296(1):104-18
1*	J:92872 Bamforth SD, Braganca J, Farthing CR, Schneider JE, Broadbent C, Michell AC, Clarke K, Neubauer S, Norris D, Brown NA, Anderson RH, Bhattacharya S, Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Nat Genet. 2004 Dec;36(11):1189-96
1*	J:165398 Barnes RM, Firulli BA, Conway SJ, Vincentz JW, Firulli AB, Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives. Dev Dyn. 2010 Nov;239(11):3086-97
1	J:171088 Barnes RM, Firulli BA, Vandusen NJ, Morikawa Y, Conway SJ, Cserjesi P, Vincentz JW, Firulli AB, Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development. Circ Res. 2011 Apr 15;108(8):940-9
1	J:41048 Biben C, Harvey RP, Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. Genes Dev. 1997 Jun 1;11(11):1357-69
1*	J:278736 Cheong A, Degani R, Tremblay KD, Mager J, A null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia. Hum Mol Genet. 2019 Aug 15;28(16):2775-2784
1*	J:64882 Christoffels VM, Habets PE, Franco D, Campione M, de Jong F, Lamers WH, Bao ZZ, Palmer S, Biben C, Harvey RP, Moorman AF, Chamber formation and morphogenesis in the developing mammalian heart [published erratum appears in Dev Biol 2000 Sep 1;225(1):266]. Dev Biol. 2000 Jul 15;223(2):266-78
1*	J:59338 Clouthier DE, Williams SC, Yanagisawa H, Wieduwilt M, Richardson JA, Yanagisawa M, Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice. Dev Biol. 2000 Jan 1;217(1):10-24
1	J:102537 Compernolle V, Brusselmans K, Franco D, Moorman A, Dewerchin M, Collen D, Carmeliet P, Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha. Cardiovasc Res. 2003 Dec 1;60(3):569-79
1	J:164028 Firulli BA, McConville DP, Byers JS 3rd, Vincentz JW, Barnes RM, Firulli AB, Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability. Dev Dyn. 2010 Oct;239(10):2748-60
1	J:243623 Freyer L, Hsu CW, Nowotschin S, Pauli A, Ishida J, Kuba K, Fukamizu A, Schier AF, Hoodless PA, Dickinson ME, Hadjantonakis AK, Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives. Cell Rep. 2017 Aug 29;20(9):2116-2130
1	J:299735 Han L, Chaturvedi P, Kishimoto K, Koike H, Nasr T, Iwasawa K, Giesbrecht K, Witcher PC, Eicher A, Haines L, Lee Y, Shannon JM, Morimoto M, Wells JM, Takebe T, Zorn AM, Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis. Nat Commun. 2020 Aug 27;11(1):4158
1*	J:93610 Harrelson Z, Kelly RG, Goldin SN, Gibson-Brown JJ, Bollag RJ, Silver LM, Papaioannou VE, Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development. 2004 Oct;131(20):5041-52
1*	J:92209 Huang F, Wagner M, Siddiqui MA, Ablation of the CLP-1 gene leads to down-regulation of the HAND1 gene and abnormality of the left ventricle of the heart and fetal death. Mech Dev. 2004 Jun;121(6):559-72
1*	J:82652 Ivey K, Tyson B, Ukidwe P, McFadden DG, Levi G, Olson EN, Srivastava D, Wilkie TM, Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme. Dev Biol. 2003 Mar 15;255(2):230-7
1	J:119923 Kokubo H, Tomita-Miyagawa S, Hamada Y, Saga Y, Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2. Development. 2007 Feb;134(4):747-55
1	J:164056 Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D, Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10894-9
1	J:175025 Lai D, Liu X, Forrai A, Wolstein O, Michalicek J, Ahmed I, Garratt AN, Birchmeier C, Zhou M, Hartley L, Robb L, Feneley MP, Fatkin D, Harvey RP, Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium. Circ Res. 2010 Sep 17;107(6):715-27
1	J:40724 Lin Q, Schwarz J, Bucana C, Olson EN, Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science. 1997 May 30;276(5317):1404-7
1*	J:149571 MacKenzie B, Wolff R, Lowe N, Billington CJ Jr, Peterson A, Schmidt B, Graf D, Mina M, Gopalakrishnan R, Petryk A, Twisted gastrulation limits apoptosis in the distal region of the mandibular arch in mice. Dev Biol. 2009 Apr 1;328(1):13-23
1*	J:181087 Mayers CM, Wadell J, McLean K, Venere M, Malik M, Shibata T, Driggers PH, Kino T, Guo XC, Koide H, Gorivodsky M, Grinberg A, Mukhopadhyay M, Abu-Asab M, Westphal H, Segars JH, The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice. J Biol Chem. 2010 Apr 16;285(16):12344-54
1	J:214961 Milgrom-Hoffman M, Michailovici I, Ferrara N, Zelzer E, Tzahor E, Endothelial cells regulate neural crest and second heart field morphogenesis. Biol Open. 2014;3(8):679-88
1	J:111702 Murray SA, Gridley T, Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10300-4
1	J:65651 Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG, Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Mech Dev. 2000 Nov;98(1-2):77-94
1	J:54067 Niederreither K, Subbarayan V, Dolle P, Chambon P, Embryonic retinoic acid synthesis is essential for early mouse post-implantation development [see comments]. Nat Genet. 1999 Apr;21(4):444-8
1*	J:83693 Porter GA Jr, Makuck RF, Rivkees SA, Intracellular calcium plays an essential role in cardiac development. Dev Dyn. 2003 Jun;227(2):280-90
1	J:116090 Risebro CA, Smart N, Dupays L, Breckenridge R, Mohun TJ, Riley PR, Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart. Development. 2006 Nov;133(22):4595-606
1	J:149166 Ruest LB, Clouthier DE, Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism. Dev Biol. 2009 Apr 1;328(1):94-108
1*	J:55840 Saga Y, Miyagawa-Tomita S, Takagi A, Kitajima S, Miyazaki Ji, Inoue T, MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube. Development. 1999 Aug;126(15):3437-47
1*	J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
1	J:78065 Shirai M, Osugi T, Koga H, Kaji Y, Takimoto E, Komuro I, Hara J, Miwa T, Yamauchi-Takihara K, Takihara Y, The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis. J Clin Invest. 2002 Jul;110(2):177-84
1	J:98806 Singh MK, Christoffels VM, Dias JM, Trowe MO, Petry M, Schuster-Gossler K, Burger A, Ericson J, Kispert A, Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2. Development. 2005 Jun;132(12):2697-707
1*	J:81324 Smart N, Hill AA, Cross JC, Riley PR, A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis. Mech Dev. 2002 Dec;119 Suppl 1:S65-71
1	J:40768 Srivastava D, Thomas T, Lin Q, Kirby ML, Brown D, Olson EN, Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND [see comments] [published erratum appears in Nat Genet 1997 Aug;16(4):410]. Nat Genet. 1997 Jun;16(2):154-60
1*	J:338018 Stathopoulou A, Wang P, Thellier C, Kelly RG, Zheng D, Scambler PJ, CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression. Cardiovasc Res. 2023 Apr 13;
1	J:98489 Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP, Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development. 2005 May;132(10):2451-62
1*	J:205662 Takeuchi JK, Lou X, Alexander JM, Sugizaki H, Delgado-Olguin P, Holloway AK, Mori AD, Wylie JN, Munson C, Zhu Y, Zhou YQ, Yeh RF, Henkelman RM, Harvey RP, Metzger D, Chambon P, Stainier DY, Pollard KS, Scott IC, Bruneau BG, Chromatin remodelling complex dosage modulates transcription factor function in heart development. Nat Commun. 2011;2:187
1*	J:47294 Thomas T, Yamagishi H, Overbeek PA, Olson EN, Srivastava D, The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness. Dev Biol. 1998 Apr 15;196(2):228-36
1	J:165022 Uchida K, Aramaki M, Nakazawa M, Yamagishi C, Makino S, Fukuda K, Nakamura T, Takahashi T, Mikoshiba K, Yamagishi H, Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis. PLoS One. 2010;5(9)
1	J:270530 Van Otterloo E, Li H, Jones KL, Williams T, AP-2alpha and AP-2beta cooperatively orchestrate homeobox gene expression during branchial arch patterning. Development. 2018 Jan 25;145(2):dev157438
1	J:196616 Willaredt MA, Gorgas K, Gardner HA, Tucker KL, Multiple essential roles for primary cilia in heart development. Cilia. 2012;1(1):23
1*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:211548 Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D, Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007 Apr 20;129(2):303-17
1	J:310871 Zheng M, Erhardt S, Ai D, Wang J, Bmp Signaling Regulates Hand1 in a Dose-Dependent Manner during Heart Development. Int J Mol Sci. 2021 Sep 11;22(18)
1*	J:41878 Zoltewicz JS, Plummer NW, Lin MI, Peterson AS, oto is a homeotic locus with a role in anteroposterior development that is partially redundant with Lim1. Development. 1999 Nov;126(22):5085-95